New research suggests that patients who stop using new weight-loss injections like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who stop traditional diet and exercise plans.
Published data in a major health publication demonstrates that while obese people often shed substantial amounts of their total mass while undergoing treatment, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"People buying these drugs must be cognizant of the risk of quick rebound weight gain when the treatment concludes," stated researcher Dr. Susan Jebb.
This pace of regain implies a reversion to pre-treatment mass in about a year and a half.
Comparing Approaches
The analysis, which looked at dozens of studies involving over 9,000 of participants, contrasted the effects of the injectable medications with other pills.
Scientists emphasize that people who shed pounds through dieting generally see a less rapid creep back—perhaps 100 grams monthly—after stopping.
The Reason for the Rapid Regain
Doctors suggest the way of the jabs accounts for the amplified weight return.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Sustained high doses of the hormone levels several times higher than normal may cause the body to produce less of its own natural hormone, and may also reduce responsiveness to its actions," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this medication leads to hunger is no longer kept in check, making overeating much more probable."
A Chronic Condition?
Health authorities advise the injections for individuals with obesity-related medical conditions, accompanied by prescribed lifestyle changes.
A number of clinicians contend that, considering the likelihood of relapse, the treatment should be considered life-long.
This opinion is reinforced by pharmaceutical companies, who say that the findings "underscore the persistent nature of excess weight," akin to managing conditions like hypertension.
Patient Accounts
People who have come off the jabs report a intense resurgence of hunger.
"I experienced something that goes on and you become starving," recalled one woman.
This challenge is compounded if individuals have not established sustainable lifestyle or habit changes during therapy.
Widespread Adoption
Figures suggest that a significant number of people in the UK have tried these injections in the last 12 months, with desire being substantial.
- Adoption is greater among females compared to males.
- The middle-aged age group shows the greatest usage rates.
- Many access the drugs through private healthcare rather than the NHS.
In conclusion, experts stress that while GLP-1 drugs are powerful tools for shedding pounds, they are not a standalone cure and maintained weight loss hinges on combined behavioural changes.
